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Utilizing the GCRLE grant, Munakata and Namekawa will appear a lot more carefully at how oocytes are genomically primed and saved for later on use. They'll investigate the role of the chromatin remodeler in oocyte survival and fertility.
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“We don’t understand how these cells are taken care of for many years,” says Namekawa. “We need to know The trick of the system.
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The GC’s tasks depend on the shipping and delivery strategy Employed in the project. By way of example, with structure-Construct tasks, either the architect or perhaps the GC manages the entire task from get started to complete. This means the GC could be answerable for taking care of both equally the design, and construction, of the project.
This protein could “create and maintain the chromatin point out,” states Namekawa — preserving the spools set up and the oocytes genetically primed because the mouse matures.
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